Design, synthesis, and structure–activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists

NJ Kim, KO Lee, BW Koo, F Li, JK Yoo, HJ Park…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 13 p. 3595 - 3598

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被引用次数: 18

摘要

... Bioorganic & Medicinal Chemistry Letters. ... In order to efficiently develop the novel PPARα/γ dual agonists, we initially attempted virtual screening of our chemical library for PPARγ (PDB number: 1K74) and then identified the compound 1 with weak PPARγ agonistic activity ...