Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor …

FC Acher, FJ Tellier, R Azerad, IN Brabet…

文献索引：Acher, Francine C.; Tellier, Frederique J.; Azerad, Robert; Brabet, Isabelle N.; Fagni, Laurent; Pin, Jean R. Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3119 - 3129

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被引用次数: 116

摘要

The four stereoisomers of 1-aminocyclopentane-1, 3, 4-tricarboxylic acid {ACPT-I (18) and-II (19),(3 R, 4 R)-III [(-)-20], and (3 S, 4 S)-III [(+)-20]} have been synthesized and evaluated for their effects at glutamate receptors subtypes. ACPTs are ACPD analogues in which a third carboxylic group has been added at position 4 in the cyclopentane ring. None of the ACPT isomers showed a significant effect on ionotropic NMDA, KA, and AMPA receptors. On the ...