Synthesis of deuterium labeled isobutane: isobutane??2??d1, isobutane??1??d9 and isobutane??d10

…, A Coeppert, J Sommer, PM Esteves…

文献索引：Sassi; Coeppert; Sommer; Esteves; Mota Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 11 p. 1023 - 1030

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被引用次数: 4

摘要

Abstract 2-Methylpropane-2-d 1 (isobutane-2-d 1), 2-(methyl-d 3)-propane-1, 1, 1, 3, 3, 3-d 6 (nonadeuterated isobutane) and 2-methylpropane-d 10 (perdeuterated isobutane) were synthesized by using a combination of classical organic chemistry and recently developed H/D exchange processes on solid acids. Isobutane-2-d 1 was synthesized from t-butyl chloride by Grignard synthesis with an overall yield of 27.0%(chemical purity: 99.9% and ...