Identification of (R)-1-(5-tert-butyl-2, 3-dihydro-1 H-inden-1-yl)-3-(1 H-indazol-4-yl) urea (ABT-102) as a potent TRPV1 antagonist for pain management

A Gomtsyan, EK Bayburt, RG Schmidt…

文献索引：Journal of Medicinal Chemistry, , vol. 51, # 3 p. 392 - 395

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被引用次数: 72

摘要

... Journal of Medicinal Chemistry. ... heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here ...