Solid-phase synthesis of chlorofusin analogues

…, AF Wilderspin, JP Malkinson, M Searcey

文献索引：Woon, Esther C. Y.; Arcieri, Mariangela; Wilderspin, Andrew F.; Malkinson, John P.; Searcey, Mark Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5146 - 5151

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被引用次数: 19

摘要

We report an efficient and versatile solid-phase synthesis through which two series of chlorofusin analogues, one bearing varying chromophores and the other with various amino acid substitutions in the cyclic peptide, were synthesized. These peptides were prepared using a strategy involving side-chain immobilization, on-resin cyclization, and postcyclization modification. The success of these syntheses demonstrates the broad ...