3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes

MS Coumar, CN Chang, CT Chen, X Chen…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1274 - 1279

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被引用次数: 12

摘要

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... By chemical modification of the lead 5, we obtained 5f with an improved DPP-IV potency (3-fold) and better selectivity (57-fold over DPP8) in comparison to 5. ...