Synlett

Asymmetric hydrogenation of heteroaromatic ketones and cyclic and acyclic enones mediated by Cu (I)-chiral diphosphine catalysts

…, T Nagano, N Sayo, T Saito, T Ohshima, K Mashima

文献索引：Shimizu, Hideo; Nagano, Takuto; Sayo, Noboru; Saito, Takao; Ohshima, Takashi; Mashima, Kazushi Synlett, 2009 , # 19 p. 3143 - 3146

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被引用次数: 14

摘要

Abstract Copper (I)-catalyzed asymmetric hydrogenation of heteroaromatic ketones, cyclic and acyclic enones is reported. The choice of the chiral diphosphine ligand highly influenced enantioselectivity as well as chemoselectivity. Highly enantioselective hydrogenation of ortho-substituted heteroaromatic ketones was achieved using BDPP as the ligand. In the 1, 2-selective hydrogenation of acylic enone, SEGPHOS gave higher ...