Chemische Berichte

Enantioselective Synthesis of Optically Active Pyridine Derivatives and C2??Symmetric 2, 2′??Bipyridines

C Bolm, M Ewald, M Felder, G Schlingloff

文献索引：Bolm, Carsten; Ewald, Martina; Felder, Marcel; Schlingloff, Gunther Chemische Berichte, 1992 , vol. 125, # 5 p. 1169 - 1190

全文：HTML全文

被引用次数: 192

摘要

Abstract Optically active pyridine derivatives 2, 15, 18, 19, 21, 26, and 27 are obtained by enantioselective reduction of the corresponding ketones 5, 7, 11–13, 24, and 25 using the chiral borane reagent chlorodiisopinocampheylborane [(I pc) 2 BCl]. Nickel (0)-mediated coupling of bromopyridines 2, 15, and 31 gives C 2-symmetric 2, 2′-bipyridines (R, R)- 32,(R, R′)-33, and (S, S)-38, respectively, which form metal complexes with Co II, Pd II, ...