Tetrahedron letters

Asymmetric alkylation of diarylmethane derivatives. Improved results using methoxyethoxy substituent

JA Wilkinson, SB Rossington, J Leonard, N Hussain

文献索引：Wilkinson, James A.; Rossington, Steven B.; Leonard, John; Hussain, Nigel Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5481 - 5483

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被引用次数: 14

摘要

Alkylation of 2-methoxyethoxyphenyl phenyl methane using sec-BuLi and (−)-sparteine has been carried out in excellent yields and up to 94% ee. The best results were obtained in allylation reactions but methylation, ethylation, benzylation and trimethylsilylation have all been carried out with acceptable ee.