Application of microbes and microbial esterases to the preparation of optically active N-acetylindoline-2-carboxylic acid

GM Ramos Tombo, HP Schär…

文献索引：Ramos Tombo, Gerardo M.; Schaer, Hans-Peter; Ghisalba, Oreste Agricultural and Biological Chemistry, 1987 , vol. 51, # 7 p. 1833 - 1838

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被引用次数: 20

摘要

Methylotrophic bacteria, isolated from soil samples or from sewage sludge, proved to be useful sources of esterases for catalyzing the enantioselective hydrolysis of racemic N-acetyl- indoline-2-carboxylic acid methyl ester (7) to the corresponding (25) or (2 R)-N-acetyl amino acid (6) with high optical yields. From the DMF-utilizer Pseudomonas DMF 5/8 and the methanol-utilizer Isolate EE 210, the corresponding esterases were isolated. Reactions ...