Archiv der Pharmazie

Synthesis and Antiviral Activity of New Substituted Methyl [2??(arylmethylene??hydrazino)??4??oxo??thiazolidin??5??ylidene] acetates

A Saeed, NA Al??Masoudi, M Latif

文献索引：Saeed, Aamer; Al-Masoudi, Najim A.; Latif, Muhammad Archiv der Pharmazie, 2013 , vol. 346, # 8 p. 618 - 625

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被引用次数: 3

摘要

A series of new methyl [2-(arylmethylene-hydrazono)-4-oxo-thiazolidin-5-ylidene] acetates (5a–o) were synthesized via cyclocondensation of thiosemicarbazones (3a–o) with dimethyl but-2-ynedioate (4) in good yields under solvent-free conditions. The environmentally friendly solvent-free protocol overcomes the limitations associated with the customary protracted solution phase synthesis and afforded the title compounds in a few minutes. ...