Synthesis of enantiomerically pure β-and γ-amino acids from aspartic and glutamic acid derivatives

…, ML Roumestant, P Viallefont, D Razafindramboa…

文献索引：El Marini; Roumestant; Viallefont; Razafindramboa; Bonato; Follet Synthesis, 1992 , # 11 p. 1104 - 1108

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被引用次数: 29

摘要

An efiicient synthesis of cnantiornerically pure 5-and y-amino acids starting from commercially available aspartic and glutamic acid derivatives is described. The acid function, at to the amino group, is first transformed to a good leaving group and the product reacted with organocuprates to yield 13-and y-amino esters. After deprotection/3-and) 1- arnino acids are obtained in good overall yields./i-Amino acids are an important class of ...