Journal of fluorine chemistry

Synthesis of fluoro-4-hydroxyquinoline-3-carboxylic acids by the Gould–Jacobs reaction

E Leyva, E Monreal, A Hernández

文献索引：Leyva, Elisa; Monreal, Elena; Hernandez, Alma Journal of Fluorine Chemistry, 1999 , vol. 94, # 1 p. 7 - 10

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被引用次数: 29

摘要

Since the discovery of the antibacterial penicillium more than 60 years ago, there has been a great deal of interest in finding new natural or synthetic compounds with antibacterial activity. The first quinolones used as antibacterial agents were nalidixic (1) and oxolinic (2) acids (Scheme. 1). However, these quinolones showed activity only against gram-negative microorganisms 1, 2 and 3. Subsequent structural modifications on these quinolones have led to new ...