Beyond the diketopiperazine family with alternatively bridged brevianamide F analogues

…, V Van Speybroeck, CV Stevens

文献索引：Heugebaert, Thomas S.A.; Van Overtveldt, Melissa; De Blieck, Ann; Wuyts, Benjamin; Augustijns, Patrick; Ponce-Gamez, Eugenia; Rivera, Alicia; De Groote, Dominic; Lefebvre, Romain A.; Wouters, Patrick; Meert, Theo; Devulder, Jacques; Stevens, Christian V. RSC Advances, 2014 , vol. 4, # 5 p. 2226 - 2234

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摘要

A method for the preparation of 3, 5-bridged piperazin-2-ones from a tryptophan–proline- based diketopiperazine is described using diphosgene to induce the ring closure. Density functional theory calculations were conducted to study the mechanism of this C–C bond