Tetrahedron

New iminophosphorane-mediated synthesis of thieno [3′, 2′: 4, 5] thieno [3, 2-d] pyrimidin-4 (3H)-ones and 5H-2, 3-dithia-5, 7-diaza-cyclopenta [c, d] indenes

MG Liu, YG Hu, MW Ding

文献索引：Liu, Ming-Guo; Hu, Yang-Gen; Ding, Ming-Wu Tetrahedron, 2008 , vol. 64, # 38 p. 9052 - 9059

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被引用次数: 59

摘要

Mono (iminophosphorane) 4 was selectively prepared from the reaction of 3, 4- diaminothieno [2, 3-b] thiophene 3 with excess triphenylphosphine, C2Cl6, and Et3N due to intramolecular double hydrogen bond formation. Mono (iminophosphorane) 4 reacted with aromatic isocyanates to give stable carbodiimides 8, which were further treated with aliphatic secondary or primary amines to give 2-amino substituted thieno [3′, 2′: 4, 5] ...