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Synthesis and cytotoxic evaluation of thiourea and N-bis-benzothiazole derivatives: A novel class of cytotoxic agents

RM Kumbhare, T Dadmal, U Kosurkar, V Sridhar…

文献索引:Kumbhare, Ravindra M.; Dadmal, Tulshiram; Kosurkar, Umesh; Sridhar; Rao, J. Venkateswara Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 453 - 455

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被引用次数: 42

摘要

Benzothiazolyl thiocarbamides has been achieved using a catalytic amount of 4- dimethylaminopyridine (DMAP) followed by its chemoselective oxidative cyclization with 1, 3- di-n-butylimidazolium tribromide [bbim][Br3] to afford the N-bis-benzothiazole derivatives. All the synthesized compounds were evaluated for cytotoxic activity against two human monocytic cell lines (U 937, THP-1) and a mouse melanoma cell line (B16-F10). Based on ...