Substituted hexahydrobenzo [f] thieno [c] quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo

MR Michaelides, Y Hong, S DiDomenico…

文献索引：Michaelides, Michael R.; Hong, Yufeng; DiDomenico Jr., Stanley; Bayburt, Erol K.; Asin, Karen E.; Britton, Donald R.; Lin, Chun Wel; Shiosaki, Kazumi Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1585 - 1599

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被引用次数: 40

摘要

A series of substituted 9, 10-dihydroxyhexahydrobenzo [f] thieno [c] quinolines (TB [f] Q), varying with respect to the position of the thiophene relative to the benzo [f] quinoline core and the nature and position of the substituent on the thiophene, were prepared and evaluated for their affinity and selectivity for the dopamine D1-like receptor. The thieno [3, 2- c] B [f] Q regioisomers bearing a small alkyl (C1-C3) substituent at the 2 position were ...