Synthesis and cytotoxic evaluation of substituted sulfonyl-N-hydroxyguanidine derivatives as potential antitumor agents

JW Chern, YL Leu, SS Wang, R Jou…

文献索引：Chern, Ji-Wang; Leu, Yu-Ling; Wang, Shan-Shue; Jou, Ruwen; Lee, Chin-Fen; Tsou, Pei-Chie; Hsu, Shih-Chung; Liaw, Yen-Chywan; Lin, Hua-Mei Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2276 - 2286

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被引用次数: 55

摘要

A series of sulfonyl-N-hydroxyguanidine derivatives was designed and synthesized for cytotoxic evaluation as potential anticancer agents on the basis of the lead compound LY- 181984. Replacement of the ureido moiety of the lead compound with hydroxyguanidine ...