Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′, 5′ bridge containing methylenebis (phosphonate) modification

AM Rydzik, M Lukaszewicz, J Zuberek…

文献索引：Organic and Biomolecular Chemistry, , vol. 7, # 22 p. 4763 - 4776

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被引用次数: 25

摘要

... Chem., 2009, 7, 4763-4776 Show Compounds Show Chemical Terms Show Biomedical Terms. ... 22 The methylene group precludes any enzymatic cleavage due to the extreme stability of P–C bonds ... 23 The analogs obtained, m 7 GpCH 2 ppG, m 2 7,3′-O GppCH 2 pG, and m 2 ...