Studies on quinolone antibacterials. IV. Structure-activity relationships of antibacterial activity and side effects for 5-or 8-substituted and 5, 8-disubstituted-7-(3-amino-1 …

…, M KAKIUCHI, Y TAKAHASHI, M ITAKURA…

文献索引：Yoshida; Yamamoto; Orita; Kakiuchi; Takahashi; Itakura; Kado; Mitani; Yasuda; Kato; Itoh Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 5 p. 1074 - 1085

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被引用次数: 29

摘要

A series of 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-1, 4-dihydro-4-oxoquinoline-3- carboxylic acids bearing various substituents (H, F, Cl, Me, OH, OMe, OEt, OCH 2 F, OCHF 2, OCF 3, SMe) at the C-8 position was prepared and evaluated for in vitro antibacterial activity against both standard laboratory strains and bacteria resistant to quinolones such as ciprofloxacin (CPFX, 1) and ofloxacin (OFLX, 2) from clinical isolates. The 8-methyl (8a), 8- ...