A Simplified Process for the Manufacture of AZD0530, a Potent SRC Kinase Inhibitor

SA Raw, BA Taylor, S Tomasi

文献索引：Raw, Steven A.; Taylor, Brian A.; Tomasi, Simone Organic Process Research and Development, 2011 , vol. 15, # 3 p. 688 - 692

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被引用次数: 3

摘要

An efficient process for the manufacture of AZD0530 1, a potent SRC kinase inhibitor, has been developed. The key transformation, reaction of monofluoroanilide 7 with alcohol 8, was much simplified between manufacturing campaigns. The development of a robust, efficient, and scalable process for this transformation drew on both a practical and theoretical understanding of the process and is described herein