Synthesis of functionalized nitroarylmagnesium halides via an iodine-magnesium exchange

…, R Lewis, N Gommermann, P Knochel

文献索引：Sapountzis, Ioannis; Dube, Henry; Lewis, Robert; Gommermann, Nina; Knochel, Paul Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2445 - 2454

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被引用次数: 57

摘要

Various nitro-substituted aryl and heteroaryl iodides undergo an iodine-magnesium exchange reaction when treated with PhMgCl leading to nitro-containing magnesium organometallics. These Grignard reagents display an excellent stability at temperatures below-40° C and do not undergo electron-transfer reactions. They react as expected with various electrophiles.