Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme …

CH Patel, S Dhanani, CP Owen, S Ahmed

文献索引：Patel, Chirag H.; Dhanani, Sachin; Owen, Caroline P.; Ahmed, Sabbir Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4752 - 4756

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被引用次数: 17

摘要

We report the preliminary results of the synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a number of phenyl alkyl imidazole-based compounds as inhibitors of the two components of 17α-hydroxylase/17, 20-lyase (P45017α), that is, 17α- hydroxylase (17α-OHase) and 17, 20-lyase (lyase). The results show that N-3-(4- bromophenyl) propyl imidazole (12)(IC50= 2.95 μM against 17α-OHase and IC50= 0.33 ...