Synthesis and Evaluation of Prolyl Carbamate Nucleic Acids (PrCNA)

Meena, VA Kumar, KN Ganesh

文献索引：Meena; Kumar; Ganesh Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1193 - 1196

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被引用次数: 1

摘要

Carbamate linked prolyl nucleic acids are obtained in high yield and purity under mild conditions in solution and solid phase. p-Nitrophenylchloroformate is used as the activating reagent for alcohol. Homooligomers of PrCNA do not bind to DNA. The introduction of this modification in PNA sequences destabilizes the triplxes, inspite of enhancement in the base stacking.