Cysteinoyl??and Cysteine??containing Dipeptidoylbenzotriazoles with Free Sulfhydryl Groups: Easy Access to N??terminal and Internal Cysteine Peptides

…, SR Tala, SA El??Feky, ZK Abdel??Samii…

文献索引：Ibrahim, Tarek S.; Tala, Srinivasa R.; El-Feky, Said A.; Abdel-Samii, Zakaria K.; Katritzky, Alan R. Chemical Biology and Drug Design, 2012 , vol. 80, # 2 p. 194 - 202

全文：HTML全文

被引用次数: 1

摘要

N-Protected cysteines 4a–c each with a free sulfhydryl group were prepared in 70–75% yields by treatment of L-cysteine with 1-(benzyloxycarbonyl) benzotriazole (Cbz-Bt) 1a, N- (tert-butyloxy-carbonyl) benzotriazole (Boc-Bt) 1b, and 1-(9-fluorenylmethoxy-carbonyl) benzotriazole(Fmoc-Bt) 1c, respectively. N-Protected, free sulfhydryl cysteines 4a–c were then converted into the corresponding N-protected, free sulfhydryl ...