4-(1, 3-Thiazol-2-yl) morpholine derivatives as inhibitors of phosphoinositide 3-kinase

R Alexander, A Balasundaram, M Batchelor…

文献索引：Alexander, Rikki; Balasundaram, Ahrani; Batchelor, Mark; Brookings, Daniel; Crepy, Karen; Crabbe, Tom; Deltent, Marie-France; Driessens, Frank; Gill, Andrew; Harris, Sue; Hutchinson, Gillian; Kulisa, Claire; Merriman, Mark; Mistry, Prakash; Parton, Ted; Turner, James; Whitcombe, Ian; Wright, Sara Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4316 - 4320

全文：HTML全文

被引用次数: 38

摘要

4-(1, 3-Thiazol-2-yl) morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo profiling of compound 18 is shown to demonstrate the utility of this class of compounds in xenograft models of tumor growth.