7-Aminoquinolines. A novel class of agents active against herpes viruses

…, SH Smith, C Shipman Jr, JH Burckhalter

文献索引：Nasr; Drach; Smith; Shipman Jr.; Burckhalter Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1347 - 1351

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被引用次数: 26

摘要

A series of 7-aminoquinoline derivatives was synthesized and evaluated for their capacity to produce cytotoxicity in KB cells and to inhibit the replication of herpes simplex virus (HSV) type 1. All compounds tested inhibited the replication of HSV-1 with 50% inhibitory concentrations in the range of 2-50 wg/mL. The antiviral activity of many compounds, however, was separated from cytotoxicity to replicating uninfected cells by only two-to ...