Synthesis and anticonvulsant activity of some substituted 1, 2, 4-thiadiazoles

…, P Mishra, SN Pandeya, SK Kashaw, V Kashaw…

文献索引：Gupta, Arun; Mishra, Pradeep; Pandeya; Kashaw, Sushil K.; Kashaw, Varsha; Stables, James P. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1100 - 1105

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被引用次数: 34

摘要

A series of new substituted 1, 2, 4-thiadiazoles were synthesized by appropriate route and screened for anticonvulsant, neurotoxic and sedative-hypnotic activity. The structures of the synthesized compounds were confirmed by IR spectroscopy, 13C NMR and elemental (nitrogen and sulphur) analysis. After ip injection of the compounds to mice or rate at doses of 30, 100, and 300mg/kg, body weights were examined in the maximal electroshock- ...