New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas …

H Yoshizawa, T Kubota, H Itani, K Minami…

文献索引：Yoshizawa, Hidenori; Kubota, Tadatoshi; Itani, Hikaru; Minami, Kyoji; Miwa, Hideaki; Nishitani, Yasuhiro Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4221 - 4231

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被引用次数: 15

摘要

Among the prepared C-3′ substituted-pyridinium cephalosporins, a series of 7β-[2-(5- amino-1, 2, 4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3- (aminoalkyl)-ureido]-1-pyridinium at C-3′ showed highly potent antibacterial activity against MRSA and Pseudomonas aeruginosa.