Abstract The influence of catalysts, acid chlorides, and solvents on the acylation of methyl 2- methyl-4 H-thieno [3, 2-b] pyrrole-5-carboxylate was studied. The use of AlCl 3 allows the regioselective introduction of the acyl group into position 3 to be performed, whereas the acyl group is regioselectively introduced into position 6 of thienopyrrole when SnCl 4 is used.