Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

KKC Liu, X Huang, S Bagrodia, JH Chen…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 4 p. 1270 - 1274

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被引用次数: 20

摘要

... Bioorganic & Medicinal Chemistry Letters. ... 11 This approach should allow us a quick entry to this newly designed iMHBS by leveraging the SAR with our knowledge on series 1 and 2, since these templates share common chemistry vectors/handles and a similar conformation. ...