5-Cinnamoyl-6-aminouracil derivatives as novel anticancer agents. Synthesis, biological evaluation, and structure-activity relationships

…, JP Henichart, V Warin, C Trentesaux…

文献索引：Bernier; Henichart; Warin; Trentesaux; Jardillier Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 497 - 502

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被引用次数: 30

摘要

A biological evaluation in the series of 5-cinnamoyl-6-aminouracils has been undertaken. These compounds have been found to be in an extended planar conformation fitting well with a possible stacking interaction between the nucleic bases of DNA; thus an eventual anticancer activity by intercalation could be hoped. 1, 3-Dimethyl-5-cinnamoyl-6-aminouracil was found to be active when administered ip against ip-implanted P388 leukemia in vivo ( ...