Tetrahedron Letters

Synthesis of a metabolite of an anti-angiogenic lead candidate based on a d-glucosamine motif

L Singh, A Lam, R Premraj, J Seifert

文献索引：Singh, Latika; Lam, Ann; Premraj, Rajaratnam; Seifert, Joachim Tetrahedron Letters, 2008 , vol. 49, # 33 p. 4854 - 4856

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被引用次数: 1

摘要

A rapid synthetic access to ACL 21269 was established in 12 steps starting from thiogylcoside 9 utilizing synthons 8 and 6 to introduce the pharmacophores at positions 1 and 2. The functional groups decorating the glucosamine scaffold were introduced in a particular order and common protecting groups were employed to establish a robust synthetic process.