Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel …

S Ayral-Kaloustian, J Gu, J Lucas…

文献索引：Goss, Rebecca J. M.; Lanceron, Simon E.; Wise, Nicola J.; Moss, Steven J. Organic and Biomolecular Chemistry, 2006 , vol. 4, # 22 p. 4071 - 4073

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被引用次数: 42

摘要

... Journal of ... J. Med. Chem. ... a Reagents and conditions: (a) succinic anhydride (n = 2) or adipic anhydride (n = 4), DCC, DMAP; (b) (1) suberic acid mono-tert-butyl ester, DCC, DMAP; (2) HCl, AcOH; (c) TMSCl, imidazole; (d) 0.5 NH 2 SO 4 ; (e) DIPC, DMAP; (f) HNR 4 R 5 . ...