Tetrahedron Letters

An aqueous medium synthesis and tautomerism study of 3 (5)-amino-1, 2, 4-triazoles

AV Dolzhenko, G Pastorin, AV Dolzhenko, WK Chui

文献索引：Dolzhenko, Anton V.; Pastorin, Giorgia; Dolzhenko, Anna V.; Chui, Wai Keung Tetrahedron Letters, 2009 , vol. 50, # 18 p. 2124 - 2128

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被引用次数: 54

摘要

A catalyst-free highly efficient synthesis of 3 (5)-amino-5 (3)-(het) aryl-1, 2, 4-triazoles in aqueous medium was performed using conventional heating and microwave irradiation. The tautomerism in the products was investigated using NMR spectroscopy and X-ray crystallography. The effects of the substitution, temperature, solvents, and concentration on the tautomerism were studied. The triazoles were found to exist in 1H-forms, the 4H-form ...