2-[N-Alkyl (R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes

…, I Briguglio, P Corona, G Paglietti, R Luciani…

文献索引：Piras, Sandra; Carta, Antonio; Briguglio, Irene; Corona, Paola; Paglietti, Giuseppe; Luciani, Rosaria; Costi, Maria Paola; Ferrari, Stefania European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 169 - 183

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被引用次数: 3

摘要

Abstract Based on our previous results on the ascertained potent growth inhibition effect against a panel of 60 human tumors cell lines at National Cancer Institute of Bethesda (NCI), we have synthesized a novel series of thirty-one 2-[N-methyl (R-phenyl)-aminomethyl]-3- phenyl-7-trifluoromethylquinoxalines (1–31). The lead compound 1 was previously reported to be endowed with significant inhibition against hDHFR enzyme, with a Ki of 0.2 μM. ...