Abstract The preparation of 4′-hydroxy-5, 6, 7-trimethoxyflavanone, 6-hydroxy-4′, 5, 7- trimethoxyflavanone, and the corresponding flavones is described as well as a new synthesis of 4′, 6-dihydroxy-5, 7-dimethoxyflavone. The results of the biological tests of these and other closely related bioflavonoids in our general endocrine screening assay are tabulated.