Design, synthesis and molecular modeling study of acylated 1, 2, 4-triazole-3-acetates with potential anti-inflammatory activity

AM Abdel-Megeed, HM Abdel-Rahman…

文献索引：Abdel-Megeed, Ashraf M.; Abdel-Rahman, Hamdy M.; Alkaramany, Gamal-Eldien S.; El-Gendy, Mahmoud A. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 117 - 123

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被引用次数: 87

摘要

The present investigation is concerned with the synthesis of different acylated 1, 2, 4-triazole- 3-acetates with the objective of discovering novel and potent anti-inflammatory agents. Structures of the synthesized compounds were elucidated by spectral and elemental analyses. The obtained compounds were evaluated for their anti-inflammatory activites as well as gastric ulcerogenic effects and acute toxicity. Results showed that 1-acylated-5- ...