A highly efficient strategy for modification of proteins at the C terminus

…, H Sun, YW Wu, G Triola, H Waldmann…

文献索引：Yi, Long; Sun, Hongyan; Wu, Yao-Wen; Triola, Gemma; Waldmann, Herbert; Goody, Roger S. Angewandte Chemie - International Edition, 2010 , vol. 49, # 49 p. 9417 - 9421

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被引用次数: 53

摘要

Site-specific protein modification can facilitate the characterization of proteins with respect to their structure, folding, and interaction with other proteins both in biochemical and in cellular investigations. Although many chemical reactions are applicable in principle, methods for the site-specific modification of proteins remain in high demand, and there is a requirement for readily available ligation reagents and mild reaction conditions.[1] Oxime-based ...