Triazole–dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration

…, X Zi, WL Lv, MM Wang, XW Ye, S Zhu…

文献索引：Hazeldine, Stuart; Pachaiyappan, Boobalan; Steinbergs, Nora; Nowotarski, Shannon; Hanson, Allison S.; Casero, Robert A.; Woster, Patrick M. Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7378 - 7391

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被引用次数: 67

摘要

... Journal of Medicinal ... azole heterocycles (pyrazole, including thiazole, imidazole, pyrrzole, oxadiazole, and triazole) have attracted more attention from medicinal chemists for many ... preferential: the p-CH 3 derivative compound 26 was more potent against LSD1 than the m-CH ...