Synthesis and biological activity of a series of diaryl-substituted. alpha.-cyano-. beta.-hydroxypropenamides, a new class of anthelmintic agents

…, PH Nelson, S Bingham Jr, AL Poulton…

文献索引：Sjogren, Eric B.; Rider, Michael A.; Nelson, Peter H.; Bingham, Stanford; Poulton, Anthony L.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3295 - 3301

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被引用次数: 23

摘要

A series of a-cyano-B-hydroxypropenamides was prepared and tested for anthelmintic activity. a-Cyano-j3-hydroxy-N-[4-(trifluoromethyl) phenyl]-3-[4-(trifluoromethyl) phenyl] propenamide (1) showed good activity against the nematode Nematospirodes dubius in a mixed parasite infection in mice; several of the analogues were also effective against the cestode Hymenolepis nana. In sheep trials, 1 caused 100% reduction of the ...