Tetrahedron Letters

N-arylation of heterocycles catalyzed by activated-copper in pure water

Q Yang, Y Wang, D Lin, M Zhang

文献索引：Yang, Qichao; Wang, Yufang; Lin, Dong; Zhang, Mingjie Tetrahedron Letters, 2013 , vol. 54, # 15 p. 1994 - 1997

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被引用次数: 17

摘要

Activated-copper powder is an efficient catalyst for the N-arylation of heterocycles with aryl halides and can be reused several times. The reactions can proceed smoothly in water by using LiOH as base and give the corresponding products in good yields. The protocol shows good tolerance toward various functional groups.