Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides

…, S Cellamare, E De Candia, C Altomare

文献索引：De Marco, Agostino; De Candia, Modesto; Carotti, Andrea; Cellamare, Saverio; De Candia, Erica; Altomare, Cosimo European Journal of Pharmaceutical Sciences, 2004 , vol. 22, # 2-3 p. 153 - 164

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被引用次数: 18

摘要

Using N-[4-(hexyloxy) phenyl] piperidine-3-carboxamide (17c) as a structural lead, a number of isomers, derivatives, and ring-opened analogs were synthesized and tested for their ability to block the in vitro aggregation of human platelets induced by adenosine 5′- diphosphate (ADP). For the most active compounds, inhibition of the platelet aggregation triggered by arachidonic acid (AA) and ADP-induced intraplatelet calcium mobilization ...