Tetrahedron Letters

The preparation of N-substituted aminomethylidenebisphosphonates and their tetraalkyl esters via reaction of isonitriles with trialkyl phosphites and hydrogen chloride …

W Goldeman, A Kluczyński, M Soroka

文献索引：Goldeman, Waldemar; Kluczynski, Artur; Soroka, Miroslaw Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5290 - 5292

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被引用次数: 7

摘要

The reaction of isonitriles with trialkyl phosphites in the presence of hydrogen chloride gives tetraalkyl N-substituted aminomethylidenebisphosphonates via N-methylideneaminium (isonitrilium) salts. Hydrolysis or dealkylation of these tetraalkyl esters gives N-substituted aminomethylidenebisphosphonic acids in high yields.