ω-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents

D Chaturvedi, S Ray, AK Srivastava…

文献索引：Chaturvedi, Devdutt; Ray, Suprabhat; Srivastava, Arvind K.; Chander, Ramesh Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2489 - 2498

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被引用次数: 10

摘要

ω-(2-Naphthyloxy) amino alkanes, obtained as major by-product during course of synthesis of carbamate esters from ω-(2-naphthyloxy) alkyl halides and amines, showed significant anti-hyperglycemic and lipid lowering activities in various test models as a novel class of compounds. Compounds were tested in rat GLM, SLM, STZ, and STZ-S models at 100mg/kg dose. Of these compound 13 was found to be the most active which caused lowering of ...