The Synthesis of Some 6-Substituted-2-thiouracils1

WH Miller, AM Dessert…

文献索引：Miller et al. Journal of the American Chemical Society, 1948 , vol. 70, p. 500

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被引用次数: 24

摘要

The synthesis of 5-and 6-substituted-2-thioura-cils froin p-oxoesters and thiourea has been reported recently by Anderson] et aL2 These compounds were evaluated in rats as antithyroid drugs3 and several were found to be more active than the parent compound, 2- thiouracil, which has been used extensively for the treatment of hyperthyroidism in man. 4 In this paper several new 6-substituted-2-thiouracils are described. Some are closely related ...