7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies

SK Sengupta, SK Tinter, H Lazarus…

文献索引：Sengupta; Tinter; Lazarus; Brown; Modest Journal of Medicinal Chemistry, 1975 , vol. 18, # 12 p. 1175 - 1180

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被引用次数: 16

摘要

The synthesis and biological activity of three 7-substituted actinomycin D derivatives are reported. Three such derivatives, $-nitro-, 7-amino-, and 7-hydroxyactinomycin D, were synthesized via new methods which were first tested successfully with a chromophore model system. Of these, 7-nitro-and 7-aminoactinomycin D were assayed for growth inhibitory activity against mammalian cells (CCRF-CEM human lymphoblastic leukemia) in vitro and ...