Synthesis and antitumor activity of some new xanthotoxin derivatives

…, NA Abdel-Latif, TK Mohamed, EY Ahmed…

文献索引：Abdel Hafez, Omaima M.; Amin, Kamellia M.; Abdel-Latif, Nehad A.; Mohamed, Tahia K.; Ahmed, Eman Y.; Maher, Timothy European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2967 - 2974

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被引用次数: 31

摘要

The condensation of 4-amino-9-methoxy psoralene (4-aminoxanthotoxin) with some aromatic aldehydes led to the formation of 4-arylimine xanthotoxin derivatives 2a–h, which were cyclized with mercaptoacetic acid to afford the thiazolidinone derivatives 3a–h. On the other hand, the reaction of aminoxanthotoxin 1 with some anhydrides afforded 4-imidione derivatives 3a–d. When 1 reacted with some isothiocyanates, the thiourea derivatives 5a– ...