Tetrahedron

A general and accurate nmr determination of the enantiomeric purity of α-aminoacids and α-aminoacid derivatives

M Calmes, J Daunis, R Jacquier, J Verducci

文献索引：Calmes, Monique; Daunis, Jacques; Jacquier, Robert; Verducci, Jean Tetrahedron, 1987 , vol. 43, # 10 p. 2285 - 2292

全文：HTML全文

被引用次数: 18

摘要

Derivatization of α-aminoacids, α-aminoesters and α-aminolactones as N-acetyl derivatives allow the accurate NMR determination of the enantiomeric purity. In these conditions the major coordination site with a chiral shift reagent will correspond to the NMR observation site. Experimental factors leading to the highest ΔΔδ values are ascertained. No straightforward correlation with absolute configurations can be established.