Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase

…, TH Lim, KA Hotchkiss, P Wilson, EL Schwartz

文献索引：Klein, Robert S.; Lenzi, Michelle; Lim, Timothy H.; Hotchkiss, Kylie A.; Wilson, Phyllis; Schwartz, Edward L. Biochemical Pharmacology, 2001 , vol. 62, # 9 p. 1257 - 1263

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被引用次数: 65

摘要

Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine and other pyrimidine 2′-deoxyribonucleosides. In addition, TP has been shown to possess angiogenic activity in a number of in vitro and in vivo assays, and its angiogenic activity has been linked to its catalytic activity. A series of 5-and 6-substituted uracil derivatives were synthesized and evaluated for their abilities to inhibit TP activity. Among the most active ...